Genetics of hypertension and atherosclerosis

This laboratory participates in large multi-center population-based genetic epdemiology studies aimed at identifying the genetic basis of cardiovascular risk factors and heart disease. The Stanford Asia Pacific Program in Hypertension and Insulin REsistance (SAPPHIRe) is an NHLBI funded study investigating the genetic basis of insulin resistance and hypertension in individuals of Japanese descent living in Hawaii, and individuals of Chinese descent living in Taiwan. This is primarily an association based case control candidate gene study. Collaborators include David Curb at the Pacific Research Institute in Haw , Rick Myers and Holly Tabor at the Stanford Human Genome Center, Ida Chen at Cedars Sinai Medical Center, and Agnes Hsiung and collegues in Taiwan. Other association based genetic studies are being conducted in the Donald W. Reynolds Center at Stanford. Two large epidemiology designs are aimed at finding genes that predispose to the development of atherosclerosis, and genes that predispose to complications of this disease. Collaborating investigators in these studies include Rick Myers and Holly Tabor, Neil Risch in the Dept. of Genetics at Stanford, Richard Olshen and Mark Hlatky in the Dept. of Health Research and Policy, and Alan Go and Carlos Iribarren at the Kaiser Division of Research.

Other Research Areas:

- Overview
- Athero
  disease
- Endothelial
  cells
- Smooth
  muscle
  cells
- Cell
  remodeling
- Apelin
- Gene
  Hunting
- SAPPHIRe
- Heart 
  developing

People involved in this project:

- Jens