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Gene Hunting, identification of novel genes that are involved in angiogenesis
Regulation of angiogenesis is one of
the most promising therapies for ischemic cardiovascular diseases as well
as cancers. Although many molecules that regulate angiogenesis have been
identified, detailed mechanism of angiogenesis still remains to be elucidated.
Objective of my project is to discover novel genes that are involved in
angiogenesis. We focused on secreted and membrane proteins because they
certainly play unique roles in angiogenesis. To identify secreted and
membrane proteins, we employed signal sequence trap based on retro-virus
expression system that is an elaborate method to catch genes with signal
sequences. We have already isolated various secreted and membrane proteins
expressed in endothelial cell. Now we are analyzing their function in
angiogenesis.
Other Research Areas:
-
Overview
- Athero
disease
- Endothelial
cells
- Smooth
muscle
cells
- Cell
remodeling
- Apelin
- Gene
Hunting
- SAPPHIRe
- Heart
developing
People involved in this project:
- Koji