Overview

This laboratory conducts molecular and population-based research into the genetic basis of cardiovascular development, function and disease. Candidate genes identified through molecular cloning and expression profiling with microarrays are investigated in molecular, cellular, and mouse genetic models to gain new insights into signaling pathways that mediate vascular development and adult pathophysiology. One funded program is aimed at defining the genes that regulate angiogenesis and vascular remodeling, as well as genes encoding novel signaling molecules and adhesion receptors. Another is aimed at understanding the molecular basis of endothelial cell gene transcription. Other programs gather information about novel genes expressed in the vascular wall in the setting of vascular disease. The laboratory also participates in collaborative studies aimed at identifying genes that predispose to the development of hypertension and atherosclerotic disease. These are large population based genetic epidemiology studies which employ cohorts collected in the Bay Area, Hawaii, and Taiwan.

Other Research Areas:

- Athero
  disease
- Endothelial
  cells
- Smooth
  muscle
  cells
- Cell
  remodeling
- Apelin
- Gene
  Hunting
- SAPPHIRe
- Heart 
  developing